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From the perspective of a novice student, the molecular biosciences are inherently invisible. A challenge facing bioscience educators is to help students create detailed mental models of the biomolecules that make up a living cell and how they all work together to support life. With the advancement of rapid-prototyping, also known as 3D (three dimensional)-printing, physical models of biomolecules are entering undergraduate classrooms as tools to aid in constructing mental models of biological phenomena at the molecular-level.This relatively new pedagogical tool requires evidence-based practices for optimal use in aiding student conceptual and visual development.This chapter presents current evidence for the use of physical models as learning tools, while also introducing case studies on how physical models of biomolecules are designed and assessed in undergraduate molecular bioscience settings.more » « less
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